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Product: Celadrin

Company: Natural Factors

Size: 90 Softgels

Ingredients: Celadrin (Proprietary blend of esterified fatty acid carbons [EFAC]) 350 mg

Encapsulated in a soft gelatin capsule (gelatin, glycerin, carob) with soy oil and salmon oil. Celadrin is a trademark of Imagenetix.

Dosage: 1 softgel, 3 times daily or as directed by a health practitioner.

Description: Celadrin - A Revolutionary Way to Manage Pain & Inflammation

The recent safety issues surrounding prescription anti-inflammatory painkillers have highlighted the need for a safe, effective alternative. Celadrin solves that problem. Celadrin achieves maximum efficacy for joint mobility and health by managing the entire range of inflammation from painful joints (osteoarthritis, tendonitis, bursitis, muscle and deep tissue pain) to psoriasis. This amazing substance is a medically and clinically proven pain management compound that is safe to use with no known side effects, reducing inflammation and pain quickly.

What is Celadrin?

Celadrin is an all-natural matrix of esterified fatty acid carbons (EFAC), sometimes referred to as cetylated fatty acids. This matrix includes myristate, myristoleate, laurate, oleate, palmitate and palmitoleate carbons, scientifically arranged through a proprietary process of esterifying oils derived from beef. As it is free of protein, it is 100 percent free of "mad cow" disease concerns.

Celadrin provides a new and different anti-arthritic action. It may be used along with other natural joint health supplements such as Glucosamine Sulfate (GLS), Chondroitin Sulfate (CS) or Methylsulfonyl-methane (MSM), empowering them to perform faster and more efficiently in building joint cartilage.

How does it work?

Celadrin works similar to, but much more dramatically than the essential fatty acids, EPA and DHA (from fish oils). Celadrin's complex blend of esterified fatty acids provides many vital and beneficial effects for the inflammatory responses in the body. Celadrin induces changes at the cellular level (in the cell membranes), that positively affect the responsiveness of the cell membranes. This aids in the reduction of cartilage breakdown in the joints. Why is helping the cell membrane so important?

The body is made up of numerous cells separated into varied types and functions. The cell membrane around each cell is the organized structure that separates and protects components in the cell from neighbouring cells and the outside world. Some of the major components of the cell membrane are structural lipids. These lipids regulate the nutrients, minerals, electrolytes, drugs and other compounds across the cell membrane. This regulation is very critical to the adequate function and health of the individual cell.

A myriad of body stressors impairs and targets the cell membrane, damaging and hindering the peak functioning and health of the membrane. When the cell membrane is severely damaged beyond a certain point, it may no longer be recognized by the immune system, resulting in an autoimmune reaction that destroys the cell. All forms of arthritis and other "autoimmune diseases" can relate somewhat to cell membrane damage.

Celadrin provides the cell membrane with an ideal blend of lipids to enhance its function, enabling the cell membrane to protect the cell, repel the stressors, and be recognized as "normal" by the immune system. Celadrin also assists in perfecting the functioning or the channeling capabilities of the cell membrane. The result is a more efficient, fluid, permeable and youthful cell membrane.

Reducing Inflammation Benefits Many Age-Related Aspects of Health

Loss of cell membrane integrity from internal and external stressors also results in a number of rapid aging processes relating to uncontrolled or imbalanced inflammation. Inflammation can occur due to age, dietary conditions, free radicals, stress or other insults which stimulate or stiffen cell membranes. This may lead to one or more forms of arthritis (bursitis and tendonitis included); periodontal disease, wrinkles, cardiovascular disease (CVD), rapid aging and many other related maladies. Celadrin not only halts the cascade of inflammation but also rapidly begins restoring the body on a cumulative basis. Flexibility is restored, pain is eliminated and the appearance of wrinkles is reversed. Celadrin accomplishes these features by enhancing the lipid structure of the cell membrane and converting it to a super membrane, enabling the cells to rapidly repair and regenerate. This unique enhancement of the cell membrane leads to the multitude of restorative, healing and age-reversing attributes of Celadrin - including arthritis and inflammatory conditions.

"The esterified (meaning they are stable and do not react with oxygen) fatty acids present in Celadrin have pronounced anti-inflammatory effects, such as the inhibition of inflammation in endothelial cells (thin cells that line the inside of some body cavities) and decreasing the pro-inflammatory effects of other fatty acids like arachidonic acid. The special fatty acids found in Celadrin have also been shown to reduce the production of the negative immune factor IL-6 and to control the immune factors responsible for inflammation. This alone could explain some of the effects of Celadrin, such as reduction of pain in joints affected by osteoarthritis. These anti-inflammatory functions are very important in preventing further tissue and joint damage while promoting healing. Additionally, the molecules found in Celadrin may play a role in the lubrication of the affected joint. This action, combined with anti-inflammatory effects, explains some of the significant improvements in mobility and function. These special fatty acids have been shown to reduce skin inflammation, while providing sustained moisturizing effects at the site of psoriasis." Lorna Vanderhaeghe (Get a Grip on Arthritis and Other Inflammatory Disorders).

What Does The Research Show?

Along with its many studies and scientific presentations, Celadrin has been published on two occasions in the internationally acclaimed Journal of Rheumatology. Celadrin systematically enhances and lubricates cell membranes throughout the body providing youthful cell fluidity and elasticity. This includes the enhancement of fluids that cushion your bones and joints to maintain flexibility and mobility so that you can move with ease and free of pain. Celadrin has been proven to provide cumulative (continuous and restorative) benefit. In a double blind clinical trial, oral Celadrin showed significant benefit beyond the other arthritic medication the subjects were taking - with cumulative improvements shown throughout the study.

The Bioavailability of Oral Celadrin

The bioavailability of cetylated fatty acids was examined in rats given oral boluses of cetylated fatty acids (similar in composition to those contained in Celadrin). Following the ingestion of the cetylated fatty acid mixture, the test animals exhibited rapid and nearly complete small intestinal absorption of test material.

How Does Celadrin Compare to CMO (Cetylmyristoleate)?
Celadrin is a complex of cetyl esters, including cetylmyristoleate, and so can be viewed as an enhanced form of CMO.


  • No reported negative side effects - over 100 million Celadrin pills distributed to date.
  • Free of the side effects associated with anti-inflammatory drugs such as Steroids, NSAIDS (e.g. aspirin), and COX 2 inhibitors (e.g. Vioxx, Celebrex).
  • Can safely be used along with other arthritic medications.
  • Although fatty acid complexes are considered safe during pregnancy, the effects of Celadrin during pregnancy and lactation have not been sufficiently evaluated. Consequently, we recommend getting the advice of a health practitioner.

    How does the dosage of Natural Factors 350mg softgel compare with the 500mg hardgel capsule or tablet forms being marketed?
    The labels on Celadrin hardgel and tableted products can be misleading. There is not 500 mg of EFA carbons per tablet or hardgel. Natural Factors Celadrin softgel contains 75% of EFA carbons while competing hardgels and tablets contain only 52.5%. Therefore, three Natural Factors Celadrin softgels deliver (1050 X 75% = 788 mg) the same amount of EFA carbons as three 500 mg tablets or hardgels (1500 X 52.5% = 788 mg).

    Why does Natural Factors use a softgel capsule to deliver Celadrin?
    Since Celadrin is a fatty acid complex, softgel capsules provided advantages in absorption, just as with other lipid-loving molecules (e.g. CoQ10). As well, the published clinical trials utilized Celadrin in a softgel form. Celadrin in hardgel capsules or tablets may not provide the same benefit.

    In Summary, Celadrin:

  • Is clinically proven effective in oral applications.
  • Will provide speedy relief to aching, painful joints, muscles and tissues.
  • Is ideal for temporary relief of minor aches and pains associated with simple backache, arthritis, strains, bruises and sprains.

    Celadrin provides safe, natural, effective help for anyone suffering from pain and inflammation, and is the ideal solution for those concerned about the serious side effects of currently available anti-inflammatory drugs and medications. You owe it to yourself to examine the research and see how these esterified fatty acids can work for you.


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    Information provided on this site is for educational use only, and is not intended as medical advice. If you have any serious health concerns you should always check with your health care practitioner before self-administering remedies.