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Product: Neptune Krill Oil

Company: Inno-Vite

Size: 60 Softgels

Ingredients: Each capsule contains: 100% Pure Neptune Krill Oil (NKO) yielding: Vitamin A 50 IU, Vitamin E 0.25 UI, Omega 3 Fatty Acids 150 mg (EPA 75 mg, DHA 45 mg), Omega 6 Fatty Acids 10 mg, Omega 9 Fatty Acids 42.5 mg, Phospholipids 200 mg, Astaxanthin 0.75 mg
Other ingredients: Gelatin (capsule), water.

Not recommended for those who are allergic to shellfish.

Dosage: Take one softgel daily with breakfast or as directed by a health care practitioner.


Nutraceutical Synergy on the Cutting Edge

The Krill is a hardy, shrimp-like creature abundant in all the oceans. Antarctic krill (Euphausia superba) are adapted to surviving Earth's coldest waters through their complement of long-chain omega-3 fatty acids - EPA (eicosapen-taenoic acid) and DHA (docosahexaenoic acid), much of which is linked to phospholipids. These provide high nutritional value and krill is a traditional food in Japan. Now from the Antarctic krill comes Neptune Krill Oil (NKO), a synergistic nutraceutical complex with novel and unusual benefits.

Made by Neptune of Canada, pure krill oil is distinct from fish oil by having a high content of phospholipids. These nutrients are called "life's building blocks" because they make cell membranes, the microscopic structures that manage most of the important business of life. Within the cell membrane system the phospholipids have a structural and functional synergy with fatty acids and antioxidants. Biochemical synergy between these three important nutraceutical classes is crucial to maintaining the conditions necessary for life (homeostasis). Krill oil is a prototype of this profound synergy.

Neptune Krill Oil (NKO): The Synergistic choice

Neptune's Krill Oil carries a high proportion of its EPA and DHA in the form of phospholipids. Much of the fatty acid content is structurally integrated with phospholipids molecules, just as occurs in cell membranes. Neptune Krill Oil typically has more than 40 percent phospholipids by weight (mostly PC, phosphatidylcholine) and upwards of 30 percent EPA + DHA. Its PC content also makes krill oil a good source of choline, an essential nutrient. Fish oils have none of these qualities - their EPA+DHA are almost totally in the form of triglycerides.

Also present in krill are potent antioxidants and these apparently make the oil exceptionally stable. For krill oil the oxidative stability index, the time for which it resists oxidation, exceeds 50 hours at 97.8 degrees Celsius. Fish oils typically do not exceed eight hours at 80 degrees Celsius, and they are notoriously unstable.

Three Potent Nutraceutical Classes in One Supplement

Clinical research on the long-chain omega-3s EPA and DHA continues at a near-feverish pace. EPA+DHA are proven essential for fetal and early childhood development. They hold exciting potential to benefit childhood learning and behavioral disorders. EPA+DHA fight inflammatory processes that drive degenerative joint, circulatory, digestive and brain diseases. They work integrally with antioxidants at the level of the cell membrane. Therein they are situated as "tails" on the phospholipids. By delivering substantial quantities of omega-3 in a similar form - co-functionalized with phospholipid molecules - krill oil helps optimize the omega-3 fatty acid benefits. And the powerful antioxidants it carries contribute to its natural synergy in support of homeostasis and against inflammation.

The carotenoid astaxanthin, small amounts of vitamin A and vitamin E, and a novel bioflavonoid all contribute to the exceptional stability and antioxidant potency of Neptune Krill Oil. The ORAC value (oxygen radical absorbance capacity) measures capacity to block the peroxy radical, one of the more common oxygen-derived radicals in vivo. In direct ORAC comparisons milligram for milligram, the value of NKO was found to be some 48 times that of fish oil and 34 times that of coenzyme Q10. This helps explain its exceptional stability against oxygen, heat and light.

Astaxanthin is a cell-membrane (lipid phase) antioxidant that is particularly effective at quenching singlet oxygen and hydroxyl radicals, two highly reactive oxygen derivatives that are by-products of cell energy production. Smoking, chemical pollutants, excessive ultraviolet exposure, antioxidant deficiency or infections can elevate these reactive free radicals to damage our cells' DNA membrane systems. Astaxanthin is very good at protecting the cell membrane phospholipids against free radical damage (peroxidation).

Astaxanthin is also an excellent protectant against ultraviolet light (UV). This helps explain why NKO protects against UV-induced skin damage, inflammation and neoplastic transformation in a mouse experiment model. Astaxanthin also has anti-inflammatory activity in animal experimental models. A study with human subjects found that astaxanthin protected LDL cholesterol against premature oxidative breakdown.

Clinical research with NKO indicates it is at least twice as biologically active as fish oils. Its main constituents, namely EPA+DHA structurally integrated with phospholipids and with potent antioxidants, have a functional synergy. It deserves to be called The Synergistic Choice.

A Wide Range of Benefits for PMS

As many as 85-97 percent of women of reproductive age experience a variety of physical discomforts and emotional problems during their monthly cycle. This symptom array is commonly called PMS (premenstrual syndrome). NKO is the first effective means for managing PMS.

Physicians of the University of Montreal, McGill University and other medical centers in Quebec conducted a double-blind, randomized, controlled clinical trial with NKO for PMS. Of 70 otherwise healthy women volunteers, 36 were placed on NKO at 2 grams/day, every day for the first month then just for 10 days of the month (eight days prior to and two days during menstruation) for the succeeding two months. A commercial "18:12" fish oil (18 percent EPA, 12 percent DHA) was given at equivalent dosage to the other 34 women. Ten parameters were measured at baseline, after 45 days and after 90 days, corresponding to those that officially define PMS. The main findings:

  • Krill oil was effective for all the menstrual difficulties, whether physical or emotional. It had a 100 percent range of benefit (all 10 of the 10 measures improved), while the fish oil was only 30 percent effective (three of the 10 measures). Krill oil worked faster, being fully effective by the second menstrual cycle while the fish oil took three cycles to reach its maximum 30 percent benefit. Unlike the krill group, 64 percent of the women taking the fish oil complained of unpleasant reflux effects.
  • Krill oil preferentially benefited breast tenderness, feeling of inadequacy, stress, irritability, depression, joint discomfort and bloating. Both groups improved on weight gain, abdominal discomfort and swelling.
  • Subjects taking krill oil reported improved alertness, energy and well-being. Their need for analgesic drugs declined. One woman said, "Both my physical and emotional symptoms have improved by nearly 100 percent… With a vivid interest, I recommend NKO to all women suffering these ailments."

    Impressive Benefits for Hyperlipidemia and Blood Sugar

    Blood lipid abnormalities - elevated LDL and total cholesterol, reduced HDL, high triglycerides - are epidemic in Western societies and contribute to heart disease. In another double-blind trial, physicians of the University of Montreal, McGill University and a medical center in Quebec, Canada compared two intake levels of Neptune's Krill Oil against one high intake level of 18:12 fish oil. The three-month trial involved 120 men and women with mild to severe hyperlipidemia.

    The subjects were randomly assigned to one of four groups (30 patients per group): krill oil 1.5 grams/day, krill oil 3 grams/day, fish oil 3 grams/day, placebo 1.5 grams/day. The trial lasted 90 days. Its main findings:

  • Krill oil at low intake (1.5 grams/day) was significantly effective at lowering total cholesterol, LDL cholesterol and the total cholesterol: HDL ratio. It elevated HDL and lowered blood sugar levels.
  • Krill oil at 1.5 grams/day achieved significantly better lowering of LDL and blood sugar than did fish oil at twice the intake - 3 grams /day.
  • Krill oil at higher dose (3 grams/day) additionally lowered blood triglycerides, while the fish oil did not. This higher dose also was superior over fish oil for lowering LDL and glucose.
  • Krill oil lacked fish oil's unpleasant aftereffects.

    In this cardiovascular trial, as with the PMS trial, Neptune's Krill Oil outperformed fish oil in benefits, potency and tolerability. These trials suggest krill oil is at least twice as effective as fish oil milligram for milligram, works faster than fish oil and completely lacks fish oil's unpleasant aftereffects.

    Omega-3 Phospholipids are Safe and Well Tolerated

    As with other phospholipids preparations, NKO has tested safe in the necessary animal and human studies and is extremely well tolerated. Healthy subjects taking NKO reported better concentration, less joint discomfort, less seasonal allergy symptoms and improved skin and hair. Since EPA+DHA are known to affect blood viscosity, Neptune recommends a warning be placed on the product's labels against co-ingestion with anticlotting medications. Also, since krill is technically seafood, those with known seafood allergies should exercise caution.

    Suggested dosing for krill oil is to begin with a high daily intake for the first 30-60 days then reduce to a maintenance level. For menstrual cycle benefits a minimum two capsules/day (1,000 mg) is suggested for the first 30-60 days, then a minimum one capsule/day (500 mg) thereafter. For cardiovascular benefits a minimum three capsules/day (1500 mg) is indicated, tapering down to one or two capsules/day once the blood lipid levels have responded. IN some individuals this could take three to four months. For more timely cardiovascular response a daily six capsules (3,000 mg) may be indicated. Intakes up to 6,000 mg/day pose no appreciable risk.

    This first-generation omega-3 phospholipid product is free from contamination. Unlike many fish oils, Neptune Krill Oil has negligible heavy metal content, very low peroxide value and very high stability. Antarctic krill is a renewable and abundant bioresource, harvested in strict compliance with international conservation requirements.

    Krill Omega-3 Phospholipids are Clinically Versatile

    Neptune's Krill Oil has great potential for further applications beyond PMS and hyperlipidemia, A larger, more comprehensive cardiovascular trial is underway. Some people who take it report improved calmness and tolerance for stress, along with higher energy and general well-being. Some said their knee shoulder, finger and other arthritic pain improved along with their joint flexibility. Currently a double-blind trial is underway with arthritic subjects. A parent from Quebec related how NKO helped her daughter recover from a serious language delay diagnosed at age three. For several years following her diagnosis this girl had great difficulty in school. Then she started taking the oil and after four months there was noticeable improvement in her language and intellectual skills. Now she is 10, is doing well in school, laughs and jokes with her friends and enjoys being "one of the girls".

    Krill oil from Neptune has proven potential to support diverse life processes at their fundamental level - the cell membrane - while simultaneously protecting against organ-level dysfunctions. It appears to be an anti-inflammatory nutraceutical complex with broad application range, suitable even for children and without the side effects of the pharmaceutical anti-inflammatories. This first-generation product places omega-3 phospholipids at the cutting edge of nutraceutical development and application.


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